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Prescribing Information

Health System Reimbursement

The resources below can help support health systems and hospitals to understand the reimbursement pathways for DefenCath.

Leverage resources below to help your health system integrate DefenCath seamlessly, from formulary inclusion to product ordering.

DefenCath Prescribing Information

Download the Prescribing Information for DefenCath (taurolidine and heparin) catheter lock solution.

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Introduction to NTAP

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NTAP Billing Guide

Download this resource for NTAP billing and coding information for inpatient use of DefenCath (taurolidine and heparin).

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TDAPA Billing Guide

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Pass-Through Payment Billing Guide

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DefenCath Product Ordering Sheet

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CRBSI = catheter-related bloodstream infection; NTAP = New Technology Add-on Payment; TDAPA = Transitional Drug Add-on Payment Adjustment.

Reference: 1. DefenCath (taurolidine and heparin) [prescribing information]. Berkeley Heights, NJ: CorMedix Inc; 2023.

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IMPORTANT SAFETY INFORMATION (cont'd)

CONTRAINDICATIONS

DefenCath is contraindicated in patients with:

  • Known heparin-induced thrombocytopenia (HIT).
  • Known hypersensitivity to taurolidine, heparin or the citrate excipient (components of DefenCath), or pork products.

WARNINGS AND PRECAUTIONS

  • Heparin-Induced Thrombocytopenia (HIT): HIT was reported in patients using heparin, a component of DefenCath, as a catheter lock solution. If HIT occurs, discontinue DefenCath and institute appropriate supportive measures.
  • Drug Hypersensitivity: Drug hypersensitivity reactions have been reported in patients using heparin, a component of DefenCath, as a catheter lock solution. If a hypersensitivity reaction occurs, discontinue DefenCath and institute appropriate supportive measures.

ADVERSE REACTIONS

The most frequently reported adverse reactions occurring in ≥2% of patients using DefenCath as a CLS were hemodialysis catheter malfunction, hemorrhage/bleeding, nausea, vomiting, dizziness, musculoskeletal chest pain, and thrombocytopenia.

To report SUSPECTED ADVERSE REACTIONS, contact CorMedix Inc at 1-844-424-6345 or FDA at 1-800-FDA-1088 or .

Indications and Usage

LIMITED POPULATION: DefenCath® is indicated to reduce the incidence of catheter-related bloodstream infections (CRBSI) in adult patients with kidney failure receiving chronic hemodialysis (HD) through a central venous catheter (CVC). This drug is indicated for use in a limited and specific population of patients.

Limitations of Use
The safety and effectiveness of DefenCath have not been established for use in populations other than adult patients with kidney failure receiving chronic HD through a CVC.

Please see the full Prescribing Information.

Proven EfficacyHow DefenCath WorksSafetyDosing and AdministrationOrdering DefenCathProduct InfoUsing DefenCathFormulary SupportHS Reimbursement
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MAT-0015 (V4.0) 03/2026

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